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From the fabled Fountain of Youth to modern cosmetic procedures, humanity’s quest for youth and longevity is as old as time. Nowadays, though, this pursuit has taken a decidedly scientific turn. As our understanding of biology expands, the focus of anti-aging efforts has shifted from the external to the internal, from the superficial to the cellular.
Understanding the aging process requires delving into the intricate world of our cells. After all, aging is not merely an external phenomenon – it is a complex biological process at the cellular level. Over time, our cells lose their ability to function optimally, leading to several adverse conditions, such as physical and cognitive decline, cardiovascular disease, and others.
RESTORIN was developed by Seragon Biosciences and is the most advanced aging intervention product. It leverages patents and collaborations with renowned institutions like Harvard University, Mayo Clinic, and Scripps Research. Its design targets fundamental aspects of aging by improving cellular health, enhancing NAD+ levels, and stimulating senolytic activity. While each component is impactful on its own, the combination of these molecular components at intentional dose levels is anticipated to lead to a synergistic effect, according to the research team’s insights.
David Brown, Ph.D., a senior scientist at Seragon, notes that senolytics can be found within RESTORIN and are researched for their potential role in organ and tissue rejuvenation by targeting something called ‘senescent cells.’
“Senescent cells are dysfunctional, pro-inflammatory cells that accumulate with age. Normally, cells have a mechanism by which they can eliminate themselves once they reach a ‘dysfunctional’ phase. Senescent cells don’t activate this elimination mechanism. They appear to suppress it actively, which leads to their accumulation. By the way, this is considered a hallmark of aging.” he explains.
Dr. Brown also highlights the importance of NAD+, a vital coenzyme involved in numerous metabolic processes, and one required for cellular life. As we age, our DNA accumulates more damage, and natural NAD+ levels in the body decline. If the body’s demand for NAD+ isn’t met, tissues and organs can deteriorate over time,” he notes.
This can ultimately lead to many health issues, including an increased risk of mortality. Dr. Brown adds, “Think of it this way: our method is unique and innovative because it’s all about the synergy. Imagine combining a series of distinct components, each precisely calibrated to optimal levels. Amplifying NAD+ has amazing potential on its own, but RESTORIN is strategically developed to address various critical aging processes that depend on NAD+.”
Additionally, RESTORIN contains sirtuin-activating compounds (STACs) – longevity proteins that can promote cellular functionality. Dr. Brown elaborates, “Sirtuins are a group of enzymes that play a crucial role in regulating various processes, such as DNA repair, boosting autophagy [a cellular waste recycler], and regulating the molecular tags typically placed on aging DNA.” By incorporating STACs into the compounds, RESTORIN could help enhance cellular health and combat the inward effects of aging.
One of the additional synergies hinted at includes capsule technology that targets the delivery of its contents at a particular point in the digestive tract. This way, the capsule acts as a targeted release system, depositing the components at a specific point and maximizing their beneficial effects.
The pursuit of longevity and improved quality of life remains a central focus in a growing scientific community. As research continues to unravel the complexities of aging at a cellular level, various technologies and approaches are being explored. From enhancing cellular health and targeting specific aging markers to broader lifestyle and dietary changes, the field is evolving with a diverse array of strategies aimed at extending not just the lifespan but also the health span of individuals. The global research community’s commitment to this cause promises to bring new insights and innovations, contributing to a future where aging is understood and addressed more effectively.
M&F and editorial staff were not involved in the creation of this content.