Cardiovascular diseases like high blood pressure, heart attacks, and congestive heart failure remain the #1 cause of death in the world. Rising rates of obesity remain a major contributor to this sad statistic. A new class of medications, peptides like semaglutide, sold as Ozempic and Wegovy, were developed as diabetic medications but produced major weight loss in most patients and are being prescribed in non-diabetics. Indeed, the craze is on and the expensive mediations are in short supply. Are the weight loss and associated benefits sustained if the medication is stopped? New data published recently answers this important question.

Study Purpose

To explore changes in body weight and cardiometabolic risk factors after treatment withdrawal in a randomized weight loss study using semaglutide or placebo.

Materials and Methods

The STEP 1 study randomized 1961 adults who were overweight or obese without diabetes to 68 weeks of once-weekly subcutaneous semaglutide 2.4 mg (including 16 weeks of dose escalation) or placebo, as an adjunct to lifestyle intervention.

At week 68, treatments (including lifestyle intervention) were discontinued.

A subset of participants was followed for a year after stopping the injections. This subset comprised all eligible participants from any site in Canada, Germany, and the UK, and sites in the United States and Japan with the highest main phase recruitment.


The study included 327 participants who were followed after stopping the injections. From week 0 to week 68, mean weight loss was 17.3% with semaglutide. Following treatment withdrawal, semaglutide and placebo participants regained 11.6 % of f lost weight, respectively, by week 120, resulting in a final net loss of 5.6% of body weight from week 0 to week 120 in the trial. About 75% of the weight was regained.

Cardiometabolic improvements that were seen from week 0 to week 68 with semaglutide reverted towards baseline at week 120 for most variables after stopping the medicine like blood pressure and blood sugar control.


One year after the withdrawal of once-weekly subcutaneous semaglutide 2.4 mg and lifestyle intervention, participants regained two-thirds of their prior weight loss, with similar changes in cardiometabolic variables.

These findings confirm the chronicity of obesity and suggest ongoing treatment is required to maintain improvements in weight and health.

There are some potentially serious side effects that can occur with these medications, including pancreatitis, kidney failure, and medullary thyroid cancer. There is also the possibility of risk to a developing fetus in a pregnant patient. Many patients experience nausea and even vomiting.

Overall, the diabetic patient staying on these medications long term for diabetic therapy may do well and sustain weight. Others who use it as a short-term crutch must focus on replacing prior lifestyles with a better diet, exercise program, sleep hygiene, and overall commitment to wellness.

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Article courtesy of Dr. Joel Kahn, MD, who is a Clinical Professor of Medicine at Wayne State University School of Medicine, one of the world’s top cardiologists, a best-selling author, lecturer, and a leading expert in plant-based nutrition and holistic care.

About the author: At his core, Dr. Joel Kahn believes that plant-based nutrition is the most powerful source of preventative medicine on the planet. Having practiced traditional cardiology since 1983, it was only after his own commitment to a plant-based vegan diet that he truly began to delve into the realm of non-traditional diagnostic tools, prevention tactics, and nutrition-based recovery protocols.

As with anything you read on the internet, this article should not be construed as medical advice; please talk to your doctor or primary care provider before changing your wellness routine. This article is not intended to provide a medical diagnosis, recommendation, treatment, or endorsement.

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