Even if you’ve never given your immune system a thought in the past, we’re willing to bet it’s been on your mind during the coronavirus pandemic. Between implementing social distancing measures and working around business closures, it’s impossible not to think about COVID-19 at the moment.

It’s key to follow guidelines set by the experts, whether that means wearing a mask at stores or staying six feet away from others in public. But when things to start to open up again and restrictions are lifted, it can’t hurt to do everything you can to keep your immune system healthy.

Staying fit and eating whole foods—along with getting sleep and regularly washing your hands—are some of the best ways to keep the sniffles and sneezing away. But when a hectic schedule starts wearing you down, a little immune system boost may be in order.

Here’s what the latest research shows when it comes to helping you sail through cold and flu season or reinforce your immune system post-pandemic. Remember, there’s no magic supplement that will protect you from getting sick altogether, and you should always check with your doctor before starting a new supplement.

Scroll through for some cutting-edge natural supplements that could help enhance your immune system and help blow off the winter blues.